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概要と使いどころ
Exploratory data-migration validation and QA ideation workflow. Use when you need to discover hidden risks, generate new validation angles, and converge mapping specs/validation reports into a prioritized QA backlog for CRM migrations. Version 2.0, updated 2025-12-28.
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Synthesized reference notes from three US Government vehicle-safety sources: NHTSA Cybersecurity Best Practices for the Safety of Modern Vehicles (updated 2022, final), NHTSA Automated Driving Systems 2.0: A Vision for Safety (2017), and a 16-section selection of 49 CFR Part 571 (FMVSS) pinned at eCFR versioner date 2025-01-01. Use for voluntary vehicle cybersecurity practices, the ADS 2.0 twelve priority safety design elements, and FMVSS occupant protection, brakes/stability/lighting, and fuel/EV integrity requirements. Not ISO 26262, not ASPICE, not ISO/SAE 21434, not UNECE R155/R156, not SAE J3016, and not the full Part 571; the FMVSS material is a selection of vehicle-level minimum performance standards, not a process standard.
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Knowledge base from the NASA Systems Modeling Handbook for Systems Engineering (NASA-HDBK-1009A Rev A, 2025). Use for model-based systems engineering (MBSE) wired into NASA's NPR 7123.1 SE processes: the three aspects of MBSE (language / methodology / framework), the NASA SE Engine and its two OOSEM-derived steps (Model Planning, Setting Up the Model), the Modeling Plan as a SEMP subset, the tool-agnostic NASA SE metamodel of elements and relationships across the four SysML pillars (structure / behavior / requirements / parametrics), worked SysML diagrams and tables for stakeholders, requirements, structure and V&V, generating SE work products (ConOps, MOE, MOP, TPM, V&V), the MBSE Grid framework, alternative modeling approaches (PBR, Scenario, System Specification, Verification), and the ConOps model-content template. Scope is bounded to four common technical processes (Stakeholder Expectation Definition, Technical Requirements Definition, Product Verification, Product Validation). Does NOT teach SysML itself, mandate a tool, define NPR 7123.1 processes, cover technical-management processes 10-17, or reproduce the OMG SysML specification.
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Knowledge base from the OUSD(R&E) guidebook Implementing a MOSA in DoD Programs (Feb 2025). Use for the Modular Open Systems Approach as a DoD acquisition + design discipline: the statutory/regulatory basis (10 U.S.C. 4401–4403, FY2017/FY2021 NDAA, DFARS), the five OUSD(R&E) pillars, the plan→modularize→identify→define→standardize interface lifecycle, technical levers (WBS/MIL-STD-881F taxonomy, standards profiling, API-first software, COTS/cybersecurity), MOSA assessment metrics and tools (PART/OAAT/KOSS/SEAM/MAUT), technology-change and DMSMS management, roadmaps, MOSA across the six AAF pathways, and contracting/IP/data-rights mechanics. SCOPE LIMITS: this is U.S. DoD weapon-system acquisition policy, not a general open-architecture or interface-standards reference — it names standards (FACE, OMS, DISR) without reproducing them, is light on detailed engineering of any specific standard, and does not cover the underlying SE processes (use dau-se-guidebook / nasa-npr-7123) or general systems-engineering theory (use sebok).
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Knowledge base from the DoD M&Q BoK (the Manufacturing and Quality Engineering Body of Knowledge), v3.0 of July 2025, published by OUSD(R&E). Use for the manufacturing-and-quality view of the defense acquisition life cycle: what M&Q engineers do across the Adaptive Acquisition Framework phases (Pre-MDD, Materiel Solution Analysis, Technology Maturation and Risk Reduction, Engineering and Manufacturing Development, Production and Deployment, Operations and Support); the twelve M&Q threads (A–L) built on the '5 Ms'; manufacturing feasibility and producibility; Manufacturing Readiness Levels and assessments; Key/Critical Characteristics and process capability (Cp/Cpk, SPC); the standards stack (AS6500, AS9100/ISO 9001, AS9103, AS9145); technical reviews (ASR/PDR/CDR/PRR) and milestone gates; DCMA surveillance; industrial base and supply chain; and sustainment (LCSP, IPS, ILA, ISR). Scope is DoD acquisition M&Q practice on the Major Capability Acquisition path — it is a best-practice compilation, not policy, and is thin on detailed shop-floor process engineering, contract law, and the full text of the cited industry standards (which it names but does not reproduce).
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Knowledge base from MIL-HDBK-61B, the DoD Configuration Management (CM) guidance handbook (7 April 2020, cataloged with Change 1, 2025). Use for defense CM across the acquisition and sustainment life cycle: the five CM functions (planning, identification, control/change management, status accounting, verification & audit), the three configuration baselines (FBL/ABL/PBL) and FCD→ACD→PCD documentation, configuration items (CIs/HWCI/CSCI), change instruments (ECP/NOR/RFV), the CCB and Class I/II classification, CDCA/AA authority, FCA/PCA audits, data management and data rights (CDRL/DID, DFARS rights ladder, master/authoritative source), and tailoring CM by phase (EIA-649-1 R/T/NR matrix, Appendix C templates), plus digital-era CM (digital twin, viewpoints, MOSA). NOTE: 61B is advisory guidance that adopts and points to the SAE EIA-649 / EIA-649-1 / GEIA-HB-649 suite for the authoritative CM requirements — this pack names and describes that suite but does not reproduce its copyrighted requirement text. Thin on: the EIA-649 requirement clauses themselves, form-level detail (DD-form field instructions, full DID content), and non-DoD/commercial CM frameworks.
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Track independent contractor payments, collect W-9s, determine 1099-NEC filing requirements, and avoid penalties. Covers the $600 threshold (2025) and $2,000 threshold (2026), Jan 31 deadline, corporate exceptions, backup withholding, and penalty schedule ($60–$660/form). Trigger on "1099", "contractor payment", "do I need to file a 1099", "W-9", "independent contractor".
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Prompt Engineering Is Dead in 2025 Introduction Prompt engineering, once hailed as the essential ski
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Artificial intelligence for modeling and understanding extreme weather ... — 24. Feb. 2025 · This re
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Native 4-bit Activations with Hadamard Transformation for 1-bit LLMs Published in arXiv , 2025 Abstract : Efficient deployment of 1-bit Large Language
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Artificial intelligence-based personalised learning in education: a ... — 18. Nov. 2025 · Thoroughly
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A review of AI edge devices and lightweight CNN and LLM deployment — 21. Jan. 2025 · However, deploy GAP: OpenHands has a modular SDK design — our too
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Model Quantization Guide: Run 70B LLMs in 4 Bits — … — 12. Okt. 2025 · Run 70B parameter LLMs on con
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Characterizing and Understanding Energy Footprint and … — 7. Nov. 2025 · This study benchmarks four GAP: OpenHands has a modular SDK design — our too
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T-SQL, stored procedures, and MS SQL Server DBA practices. Use when writing SQL queries, designing schemas, tuning SQL Server performance, managing backups, configuring security, or using SQL Server 2025+ features.
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Build 3D scenes and visualizations using SceneKit. Use when creating 3D views with SCNView and SCNScene, building node hierarchies with SCNNode, applying materials and lighting, animating with SCNAction, simulating physics with SCNPhysicsBody, loading 3D models (.usdz, .scn), adding particle effects, or embedding SceneKit in SwiftUI with SceneView. Note: SceneKit was deprecated at WWDC 2025 and is in maintenance mode; RealityKit is recommended for new projects.
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Advanced vulnerability analysis principles. OWASP 2025, Supply Chain Security, attack surface mapping, risk prioritization.
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Auri: assistente de voz inteligente (Alexa + Claude claude-opus-4-20250805). Visao do produto, persona Vitoria Neural, stack AWS, modelo Free/Pro/Business/Enterprise, roadmap 4 fases, GTM, north star WAC e analise competitiva.
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Detects prompt injection attacks targeting LLM-based applications using a multi-layered defense combining regex pattern matching for known attack signatures, heuristic scoring for structural anomalies, and transformer-based classification with DeBERTa models. The detector analyzes user inputs before they reach the LLM, flagging direct injections (system prompt overrides, role-play escapes, instruction hijacking) and indirect injections (encoded payloads, multi-language obfuscation, delimiter-based escapes). Based on the OWASP LLM Top 10 (LLM01:2025 Prompt Injection) and Simon Willison's prompt injection taxonomy. Activates for requests involving prompt injection detection, LLM input sanitization, AI security scanning, or prompt attack classification.
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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.
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Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2016 non-inferiority margin selection with M1/M2 framework; Schoenfeld 1981 and Lakatos 1988 for survival; Schuirmann TOST and 80-125% bioequivalence; minimum clinically important difference (MCID) vs δ distinction. Use when justifying trial size in protocol or SAP per CONSORT 2025 item 7.
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RNN+Transformer hybrid with O(n) inference. Linear time, infinite context, no KV cache. Train like GPT (parallel), infer like RNN (sequential). Linux Foundation AI project. Production at Windows, Office, NeMo. RWKV-7 (March 2025). Models up to 14B parameters.
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End-to-end clinical trial analysis workflow from CDISC SDTM/ADaM loading through ICH E9(R1) estimand-driven primary analysis to CONSORT 2025 regulatory-compliant reporting. Covers data preparation, FDA 2023 marginal vs conditional logistic regression, categorical tests with Boschloo, modern HTE/subgroup methods, missing-data sensitivity (MMRM, reference-based MI, Permutt tipping point), graphical multiplicity (Bretz-Maurer), survival analysis (Cox/RMST/competing risks) when applicable, and Table 1. Use when performing a complete analysis of clinical trial data.
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Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al 2022/2023 J Chem Inf Model 63:147-158), Pharmer / Pharmit (search), and PharmacoForge (diffusion-based generation, Flynn et al 2025 Front Bioinform), covering ligand-based pharmacophore (from active set alignment) and receptor-based pharmacophore (from binding pocket geometry). Explicit handling of feature types, geometric tolerances, partial matching, and pharmacophore-based virtual screening. Use when identifying scaffold-hopping candidates, building shape-and-feature search queries, or transferring SAR across chemotypes.
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