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概要と使いどころ
Decompose genetic effects into direct and indirect paths through mediating variables using the mediation R package. Tests whether gene expression, methylation, or other molecular phenotypes mediate the effect of genetic variants on disease. Use when testing whether a molecular phenotype mediates the genotype-to-phenotype relationship.
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Test whether two traits share a causal variant at a genomic locus using Bayesian colocalization with coloc. Computes posterior probabilities for shared vs distinct causal variants between GWAS and eQTL signals. Use when determining if a GWAS signal and an eQTL share the same causal variant.
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Estimate causal effects between exposures and outcomes using genetic variants as instrumental variables with TwoSampleMR. Implements IVW, MR-Egger, weighted median, and MR-PRESSO methods for robust causal inference from GWAS summary statistics. Use when testing whether an exposure causally affects an outcome using genetic instruments.
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Autonomously screen NYSE, Nasdaq, and NYSE American operating-company stocks for undervalued-growth/GARP opportunities using forward same-basis valuation, driver-derived EPS/FCF forecasts, primary-source financial verification, SBC and dilution controls, sector and cycle normalization, auditable candidate-pool coverage, and fail-closed final reporting. Use when asked to find, screen, rank, or refresh US undervalued-growth stocks, including minimal requests with no ticker list or parameters.
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Select the best MetaTrader 5 trading robots (Expert Advisors) that have not been backtested yet, by running the MT5 Strategy Tester from the command line through a 3-round pipeline. Use when the user wants to batch-test MT5 bots/EAs, screen robots across all symbols, optimize EA parameters, or move candidate bots to finalists based on profit, drawdown, positive months/years and equity-curve criteria. Runs terminal64.exe headless; Windows + MetaTrader 5 required at run time.
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Statistical arbitrage tool for identifying and analyzing pair trading opportunities. Detects cointegrated stock pairs within sectors, analyzes spread behavior, calculates z-scores, and provides entry/exit recommendations for market-neutral strategies. Use when user requests pair trading opportunities, statistical arbitrage screening, mean-reversion strategies, or market-neutral portfolio construction. Supports correlation analysis, cointegration testing, and spread backtesting.
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Expert guidance for systematic backtesting of trading strategies. Use when developing, testing, stress-testing, or validating quantitative trading strategies. Covers "beating ideas to death" methodology, parameter robustness testing, slippage modeling, bias prevention, and interpreting backtest results. Applicable when user asks about backtesting, strategy validation, robustness testing, avoiding overfitting, or systematic trading development.
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Review skills in any project using a dual-axis method: (1) deterministic code-based checks (structure, scripts, tests, execution safety) and (2) LLM deep review findings. Use when you need reproducible quality scoring for `skills/*/SKILL.md`, want to gate merges with a score threshold (for example 90+), or need concrete improvement items for low-scoring skills. Works across projects via --project-root.
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Operate a selective workspace for complex reasoning, long tasks, repository engineering, coordinated agents, and authorized security analysis. Use when work requires durable state, evidence, cross-file consistency, or recovery; keep direct answers lightweight.
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Reviews financial documents (prospectuses, ADVs, marketing materials) for FINRA 2210 compliance, required disclosures, and balanced presentation. Use when reviewing financial statements, audit documents, regulatory filings, or when the user mentions compliance checks, financial audits, or document verification.
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Memory integrity audit. Detects hallucinations, circular confirmations, and state poisoning. Runs automatically after 2 consecutive failures or at nightly deep dive. Uses Opus 4.6 as the auditor model.
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Analyzes documents and processes against FINRA, SEC, Federal Reserve, and CFPB regulatory frameworks. Identifies compliance gaps, classifies findings by severity, and recommends remediation. Use when performing compliance audits, regulatory reviews, gap analyses, or verifying policy adherence to financial regulations.
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Use when the user asks to "run the weekly social readout", "which denominator does our engagement rate use", or "which posts won this week and what changes next cycle"; produces the organic-social metric dictionary (every rate names its denominator — ERR engagement-by-reach vs ERI by-impressions vs ER-by-follower — locked across periods), median-not-mean per-post rollups with organic and boosted separated, EMV as labeled exec-translation only (never inside any score), an attributed CHAOSS/Orbit-style community-health readout with employees excluded, and the best/worst-performer write-back the next calendar cycle consumes. Not for dollar-ROI math or the ECHO profile result gate verdict — use roi-calculator and social-quality-auditor. 社媒周报/互动率分母/指标字典/复盘回写
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Use when the user asks to "build our social crisis protocol", "mentions are exploding — what do we do first", or "when do we pause the posting queue"; produces a 1-5 severity ladder with tunable Estimated trigger thresholds (mention-velocity multiples vs the 7-day listening baseline, sentiment flip, journalist/regulator contact, employee-conduct class), the first-mechanical-action rule — pause ALL scheduled posts AND paid amplification, with dated state markers dropped to the channels proposal protocol and reconciled post-incident — a pre-approved holding-statement library with committed update cadences, when-NOT-to-post rules, a spokesperson/approval matrix, and a post-crisis retro template; re-runs the social-quality-auditor pre-publish gate before un-pausing the queue. Not for email deliverability incidents (blocklist, spam-rate spikes) — use deliverability-qa; inside a launch window launch-day-conductor owns incident handling. 社媒危机预案/暂停队列/声明库/发言人矩阵
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Use when auditing content quality, E-E-A-T, or publish readiness; runs a typed 80-item CORE-EEAT profile with evidence coverage, veto checks, and a fix plan. Not for structural tags/headers alone — use on-page-seo-checker; not for domain/citation trust — use domain-authority-auditor. 内容质量/EEAT评分
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Use when the user asks to "audit our social presence" or "is this batch safe to publish"; runs either the typed ECHO asset gate or a separate program-maturity profile, with channel-truth, claim, disclosure, manipulation, UGC-rights, and denominator checks. Not for creator deliverables — use creator-content-auditor; not for launch readiness — use launch-readiness-auditor. 社媒资产门/运营成熟度/发布前放行
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Use when the user asks to "package our proof points", "build reusable stat cards and case snippets", or "put proof where each pillar makes its claim"; turns claims-ledger-approved proofs into reusable proof modules — stat cards, case snippets, testimonial blocks, comparison proofs — each pinned to a message-house pillar and the ledger claim ID it substantiates, and flags any pillar making a claim with no approved proof behind it. Never adjudicates a proof: unverified or ledger-absent proofs are marked '[needs source]' and routed to the claims candidates. Not for adjudicating or substantiating claims — use offer-claims-registry; not for fabricating a benchmark to fill a gap — a missing proof is flagged, not invented; not for scoring narrative quality — use narrative-quality-auditor. 证据模块/证据卡/客户案例/主张对齐
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Use when the user asks to "map what our surfaces say today", "inventory our current messaging", or "find the gap between what we say and what we mean"; produces the narrative baseline — a surface-by-surface inventory of what every owned touchpoint (homepage, pricing, docs, decks, social bios, email footers) claims RIGHT NOW, each line labeled Measured / User-provided / Estimated, plus a per-surface gap read vs the intended message and the drift-baseline snapshot the Evaluate phase measures future drift against. Not for authoring the canon — use message-system-architect; not for scoring the surfaces or running the vetoes — use narrative-quality-auditor. 现状叙事盘点/各触点口径/意图差距/漂移基线
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Use when the user asks to "audit our launch plan", "are we ready to launch", or evaluate launch execution/outcomes; runs one typed RAMP preflight, execution, or outcome profile without mixing time horizons. Not for recording launch state — use launch-registry; not for running launch day — use launch-day-conductor. 发布就绪审计/RAMP分阶段评估/发布前放行
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Use when auditing domain authority, trust, or citation credibility; runs a peer-relative 40-item CITE profile with evidence coverage and verified manipulation/penalty veto checks. Not for page-level content quality — use content-quality-auditor; not for backlink profiling alone — use offsite-signal-analyzer. 域名权威/网站可信度
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Use when the user asks to "test our messaging before we scale it", "design a message-market-fit panel", or "run a 5-second comprehension test on our new tagline"; produces a message-test design spec — hypothesis, panel and recruit criteria, comprehension / 5-second / message-market-fit (Wynter-style) protocols, stimulus set drawn from the canon, success thresholds, and a stop/revise decision rule — for the TALE Evaluate phase so the message is validated before any paid scale. It designs the test; it never runs the experiment or adjudicates a claim. Not for running the panel or A/B experiment — use send-experiment-designer or ad-test-designer; not for analyzing the results — use performance-analyzer; not for authoring the message itself — use message-system-architect. 消息测试/理解度测试/面板设计/五秒测试/消息市场契合
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Use when the user asks to "build programmatic SEO pages", "generate pages at scale", "rank on a high-authority third-party site", "borrow domain authority", "build a vs / alternative page", "do local SEO", "optimize a Google Business Profile", or "fix NAP" — one page-build router with four modes: programmatic (template × dataset systems), parasite (barnacle publishing on Medium/Reddit/LinkedIn/GitHub), comparison (vs / alternative pages in four formats), and local (GBP + NAP + citations + location pages), each with its own thin/duplicate, honesty, or reputation-abuse guardrail. Not for finding what to target — use keyword-research or content-gap-analysis; not for drafting one standalone article — use content-writer; not for scoring a page for publish — use content-quality-auditor. 程序化SEO/批量页面/寄生SEO/借势权重/对比页/vs页/替代页/本地SEO/谷歌商家档案/NAP一致性
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Use when the user asks to "run my launch day", "build a launch day runbook / war room", or "decide CONTINUE or ROLLBACK after the push"; produces a pre-conditions gate check (launch-readiness-auditor SHIP verdict + the authoritative date in launch-registry — missing either stops the skill), a dated hour-blocked runbook with owners (morning irreversible pushes, daytime monitoring loop, evening consolidation), a forced observation-window verdict after every irreversible action against pre-declared kill criteria, a P0-P3 incident ladder with rollback playbooks, and T-0 status lines for the registry proposal protocol. Not for channel submission content and platform rules — use community-launch-runner; not for media replies — use press-media-relations. 发布日runbook/作战室/观察窗/回滚裁决/发布日指挥
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Use when the user asks to "audit our brand narrative" or "is this message on-canon"; runs separate typed TALE truth, system, or effectiveness profiles and never averages them into one composite. Checks differentiation, canon, landing consistency, and evidence integrity. Not for launch readiness — use launch-readiness-auditor; not for social operations — use social-quality-auditor. 品牌叙事分层审计/发布前一致性放行
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