「complex」の検索結果

Work on bifunctional degraders and molecular glues, where potency comes from a ternary complex rather than occupancy. Use this skill to apply the property rules that govern this beyond-rule-of-five space, reason about linker length, attachment vector and E3 ligase choice, prepare inputs for ternary complex structure prediction, and interpret degradation readouts — DC50, Dmax, cooperativity, and the hook effect that makes a dose-response curve turn over. Also trigger on PROTAC, molecular glue, targeted protein degradation, E3 ligase, cereblon, VHL, ternary complex, DC50, Dmax, hook effect, cooperativity, or PROTAC-DB.

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Coordinate structured thinking and multi-agent parallel execution for complex tasks. Use when tackling multi-step projects, planning parallel work, breaking down complex problems, coordinating specialist tasks, facing architectural decisions, or when user mentions "workflow", "orchestration", "multi-step", "coordinate", "parallel execution", "structured thinking", "break this down", "plan this out", "how should I approach", or needs help planning complex implementations.

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Domain-aware complexity routing: scans the task for domain keywords, matches domain-complexity.csv, and returns complexity level, workflow intensity, and execution tier. Extends Phase 0 orchestration.

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Analyzes ticket complexity and maps dependencies against an existing codebase before sprint planning. Triggers on 'how complex is this ticket', 'what should we work on first', 'can we fit this in the sprint', 'tech review before planning', 'plan the sprint'. NOT for writing implementation plans (see mk:plan-creator); NOT for scope/ambition review (see mk:plan-ceo-review).

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Evaluate Jira ticket complexity + inconsistencies via the jira-evaluator agent. Read-only. Triggers: 'evaluate KEY', 'analyze ticket complexity for KEY', 'check ticket quality for KEY'. NOT for estimation (mk:jira-estimator); NOT for full RCA (mk:jira-analyst).

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This skill recommends lifelong follow-up tests for cardiac myxoma and associated disease (testicular tumors, acromegaly, thyroid lesions) in patients with Carney complex. Use when managing a Cushing’s syndrome patient with a confirmed or suspected Carney complex diagnosis (e.g., spotty skin lentigines, cardiac myxoma, endocrine tumors).

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Expert-level complex analysis knowledge. Use when working with complex functions, holomorphic functions, Cauchy's theorem, contour integration, Laurent series, residues, conformal mappings, or analytic continuation. Also use when the user mentions 'holomorphic', 'analytic', 'Cauchy theorem', 'residue', 'contour integral', 'Laurent series', 'conformal map', 'Riemann mapping', 'Mobius transformation', 'harmonic function', 'entire function', or 'meromorphic'.

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Two-phase code quality skill: (1) review codebase for structural smells — file LOC, method LOC, accidental complexity, test readability — producing a structured report, then (2) fix all smells via provable refactorings with ACN micro commits and green-bar-at-all-times discipline. Use this skill when the user says 'sweep', 'code review', 'find code smells', 'check method lengths', 'review for complexity', 'tidy up the codebase', 'refactor smells', or asks about long methods, test readability, or accidental complexity. Also trigger when users ask to 'clean up' or 'improve code quality' across multiple files.

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Decompose tasks into structured, outcome-defined process entries with complexity triage. Load when user says "decompose this", "break this down", "what steps do I need", "plan this out", "what's the process for", "how do I approach this", or when any complex task needs structured execution planning. Includes a problem-understanding pass before complexity triage. Routes to `problem-to-plan` when the user needs planning deliverables (spec + plan + TODO). Does NOT replace brainstorming — brainstorming is design approval (upstream), this is execution planning (downstream).

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Atom of Thoughts (AoT) reasoning - decompose complex problems into atomic units with confidence tracking and backtracking. For genuinely complex reasoning, not everyday questions. Triggers on: atomise, complex reasoning, decompose problem, structured thinking, verify hypothesis.

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呼び出し側が覚える使い方を小さく保ち、複雑な処理を内部にまとめる設計を支援します。共通の用語と判断基準で、モジュールの使いやすさやテストのしやすさを検討するスキルです。

• モジュールの使い方を簡単にしたいとき
• 散らばった複雑な処理をまとめたいとき
• 実装を差し替える場所の検討

LLM APIの費用を抑えるため、作業の複雑さに応じたモデル選択、予算の記録、一時的なエラーの再試行、共通プロンプトのキャッシュを組み合わせる設計例を示します。

• LLMアプリのAPI費用を見直したいとき
• 一括処理の難易度でモデルを選びたいとき
• 予算に対する累積費用の確認

State-space model with O(n) complexity vs Transformers' O(n²). 5× faster inference, million-token sequences, no KV cache. Selective SSM with hardware-aware design. Mamba-1 (d_state=16) and Mamba-2 (d_state=128, multi-head). Models 130M-2.8B on HuggingFace.

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State-space model with O(n) complexity vs Transformers' O(n²). 5× faster inference, million-token sequences, no KV cache. Selective SSM with hardware-aware design. Mamba-1 (d_state=16) and Mamba-2 (d_state=128, multi-head). Models 130M-2.8B on HuggingFace.

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Optimizes SQL queries, designs database schemas, and troubleshoots performance issues. Use when a user asks why their query is slow, needs help writing complex joins or aggregations, mentions database performance issues, or wants to design or migrate a schema. Invoke for complex queries, window functions, CTEs, indexing strategies, query plan analysis, covering index creation, recursive queries, EXPLAIN/ANALYZE interpretation, before/after query benchmarking, or migrating queries between database dialects (PostgreSQL, MySQL, SQL Server, Oracle).

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Generates Mermaid diagrams from Trailmark code graphs. Produces call graphs, class hierarchies, module dependency maps, containment diagrams, complexity heatmaps, and attack surface data flow visualizations. Use when visualizing code architecture, drawing call graphs, generating class diagrams, creating dependency maps, producing complexity heatmaps, or visualizing data flow and attack surface paths as Mermaid diagrams.

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Predict structures and binding for one defined complex with Boltz. Use when folding a protein, RNA, DNA, or ligand complex, docking one ligand, predicting an interface, or scoring binding. Not for screening libraries or design.

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Plan complex Blazor UI features by decomposing them into focused components. USE FOR: building a complex Blazor page with multiple sections, planning component decomposition, designing a multi-section dashboard or layout, breaking down a large UI feature into composable components, pages with sidebars and content panels, any page with 3+ distinct visual sections or multiple interacting sub-features, identifying parent-child relationships and data flow. DO NOT USE FOR: creating new Blazor projects or apps from scratch (use create-blazor-project), implementing a single individual component (use author-component), writing component code with parameters and EventCallback (use author-component), or simple single-component pages.

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Structure prediction for protein, nucleic-acid, and small-molecule complexes with the Chai-1 foundation model (Chai Discovery 2024, github.com/chaidiscovery/chai-lab). Reach for this skill to predict an antibody-antigen or protein-ligand complex from a single FASTA, to re-fold designed binders as an AlphaFold-multimer alternative, or to drive co-folding from Python for batched campaigns on a GPU.

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Keep code, tests, documentation, configuration, and other changes as tight, clear, performant, and minimal as possible without weakening behavior. Use during implementation to prevent unnecessary complexity, after behavior is proven to consolidate working changes, before handoff for a full branch audit, and when asked to simplify, tighten, clean up, reduce verbosity, remove complexity, or minimize existing work.

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Problem-solving with Rudin's Real and Complex Analysis textbook

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Token-efficient code analysis via 5-layer stack (AST, Call Graph, CFG, DFG, PDG). 95% token savings.

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Implements Manus-style file-based planning for complex tasks. Creates task_plan.md, findings.md, and progress.md. Use when starting complex multi-step tasks, research projects, or any task requiring >5 tool calls.

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Validate protein designs using AlphaFold2 structure prediction. Use this skill when: (1) Validating designed sequences fold correctly, (2) Predicting binder-target complex structures, (3) Calculating confidence metrics (pLDDT, pTM, ipTM), (4) Self-consistency validation of designs, (5) Multi-chain complex prediction with AlphaFold-Multimer. For faster single-chain prediction, use esm. For QC thresholds, use protein-qc.

日本語の概要は準備中です。原文の説明を表示しています。