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AiZynthFinder retrosynthetic route planning (CASP) from AstraZeneca Molecular AI. Monte Carlo tree search guided by a template-based neural expansion policy recursively disconnects a target SMILES until precursors are found in a purchasable stock. Covers config.yml (v4 format), aizynthcli batch screening, the AiZynthFinder/AiZynthExpander Python API, one-step disconnections, custom stocks via smiles2stock, scorers, Retro*/breadth-first/DFPN search alternatives, and reading output.json.gz / trees.json. Use for synthesis route planning, synthesizability screening, and building-block/precursor search. For reaction barriers use neb-irc-activation-energy; for 2D reaction scheme drawing use rdkit-chemdraw-cdxml.

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GRN inference from expression via GRNBoost2 (gradient boosting) or GENIE3 (Random Forest). Load matrix, filter by TFs, infer TF-target-importance links, save network. Dask-parallelized to single-cell scale. Core SCENIC component.

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Access real-time and historical stock market data, forex rates, cryptocurrency prices, commodities, economic indicators, and 50+ technical indicators via the Alpha Vantage API. Use when fetching stock prices (OHLCV), company fundamentals (income statement, balance sheet, cash flow), earnings, options data, market news/sentiment, insider transactions, GDP, CPI, treasury yields, gold/silver/oil prices, Bitcoin/crypto prices, forex exchange rates, or calculating technical indicators (SMA, EMA, MACD, RSI, Bollinger Bands). Requires a free API key from alphavantage.co.

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Search and retrieve preprints from arXiv via the Atom API. Use this skill when searching for papers in physics, mathematics, computer science, quantitative biology, quantitative finance, statistics, electrical engineering, or economics by keywords, authors, arXiv IDs, date ranges, or categories.

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Access AlphaFold DB's 200M+ predicted structures by UniProt ID. Download PDB/mmCIF, analyze pLDDT/PAE, bulk-fetch proteomes via Google Cloud. For experimental structures use PDB; for prediction use ColabFold or ESMFold.

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Word (.docx) manipulation via MCP server. Use for reading, creating, editing, formatting Word documents including tables, footnotes, comments, images, headers, styles, and PDF conversion.

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12-agent academic paper writing pipeline. 11 modes (full/plan/outline/revision/revision-coach/abstract/lit-review/format-convert/citation-check/disclosure/rebuttal-audit). 6 paper types, 5 citation formats, bilingual abstracts, LaTeX/DOCX-via-Pandoc/PDF output. Style Calibration + Writing Quality Check + Anti-Patterns with IRON RULE markers. Triggers: write paper, academic paper, guide my paper, parse reviews, audit my rebuttal, check my response draft, AI disclosure, 寫論文, 學術論文, 引導我寫論文, 審查意見, 評估回覆, 논문 작성, 초록 작성, 논문 수정, 논문 계획을 도와줘, 심사 의견 반영, 답변서 점검, AI 사용 고지.

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Train and fine-tune transformer language models using TRL (Transformers Reinforcement Learning). Supports SFT, DPO, GRPO, KTO, RLOO and Reward Model training via CLI commands.

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Contribute skills back to upstream via branch and PR

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Breadboard circuit mockups via HTML5 Canvas. Use when creating circuit layouts, visualizing 6502/retro electronics components, drawing breadboard diagrams, or designing vintage computer schematics with discrete parts.

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Use when the task requires automating a real browser from the terminal (navigation, form filling, snapshots, screenshots, data extraction, UI-flow debugging) via `playwright-cli` or the bundled wrapper script.

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Microsoft docs lookup, code samples, and SDK reference for Azure, .NET, Microsoft 365, Windows, and Power Platform via Microsoft Learn MCP. Use for API reference or official MS documentation retrieval.

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Transform, resize, crop, reformat, and optimize images on demand via Netlify Image CDN's /.netlify/images endpoint. Use when adding responsive images, generating thumbnails, converting formats (avif/webp/png), cropping to aspect ratios, tuning image quality, creating blurred placeholders, allowlisting remote image domains, serving user-uploaded images, or wiring framework image components (Next.js, Astro, Nuxt, Angular, Gatsby) to Netlify. Triggers on tasks like "optimize images", "add image thumbnails", "resize images on the fly", "serve images from an external domain", or "add blur placeholders".

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Zero-config Postgres for Netlify apps via @netlify/database — querying data from Functions/Edge Functions, writing schema migrations, setting up Drizzle ORM, local dev with netlify dev, database branches for deploy previews, and migrating an existing Postgres project onto Netlify. Use when adding a database, building a contact form or CRUD API, writing SQL migrations, wiring up Drizzle, running netlify database commands, testing with a local Postgres, or switching from Neon/Supabase/RDS to Netlify Database.

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Serverless form handling on Netlify-hosted sites — detects HTML forms at deploy time, stores submissions, filters spam, and sends notifications. Use when adding a contact form, lead-capture form, file-upload form, or newsletter signup to a Netlify site; wiring AJAX form submission; setting up a custom thank-you page; adding a honeypot or reCAPTCHA to a form; getting forms working in Next.js, Nuxt, SvelteKit, Astro, or Gatsby; reading form submissions via the Netlify API; or debugging missing submissions and forms that silently fail to register.

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Notion workspace management via MCP - create databases, pages, comments, and knowledge bases. Use when building Notion documentation, organizing project wikis, or managing Notion content.

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Cache dynamic and static responses on Netlify's CDN from Functions, Edge Functions, and proxies. Use when you add caching or cache-control headers to a function response, tune cache TTL or stale-while-revalidate, set up the durable cache, vary a cache key by query/header/cookie/country/language, purge or invalidate the cache by site or cache tag, use the programmatic Cache API (caches.open/match/put) or @netlify/cache helpers (fetchWithCache/cacheHeaders/getCacheStatus), speed up an expensive API call, add ISR or on-demand revalidation, or debug why a response is or isn't cached via the Cache-Status header.

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PowerPoint (.pptx) manipulation via MCP server. Use for creating slides, formatting presentations, managing placeholders, adding images, applying templates, or extracting text from .pptx files.

日本語の概要は準備中です。原文の説明を表示しています。

Power BI semantic models - DAX measures, star schemas, relationships, RLS, and performance tuning via MCP. Use when creating data models, writing DAX, or configuring table relationships in Power BI.

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Configure Netlify projects via netlify.toml and the _headers/_redirects files — covering build settings and deploy contexts alongside environment variables/scopes and the Secrets Controller plus redirect/rewrite/proxy and custom-header rules. Use when setting a build command or publish directory, adding redirect or rewrite or proxy rules, configuring custom headers or basic auth, setting or scoping environment variables and secrets, wiring up a monorepo or SPA fallback, or skipping unnecessary builds. Reach for this whenever you touch netlify.toml or ask "why is my env var undefined in a function" or "how do I redirect this path".

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Motion / animation context for the `use_figma` MCP tool — animating Figma nodes via manual keyframes, animation styles, easing, and timeline duration. Load alongside figma-use whenever a task involves adding, editing, or inspecting animation on a node.

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Create a SageMaker endpoint (real-time, real-time scale-to-zero, or async) with autoscaling, CloudWatch alarms, and tagging enabled by default. Use this skill whenever about to create a SageMaker endpoint, write deployment code that calls `create_endpoint`, or finalize a deployment after the image URI and IAM role are known. Provides deploy.py for real-time endpoints, deploy_ic.py for real-time endpoints that scale to zero instances via inference components, and deploy_async.py for async endpoints (also scale-to-zero). This is the last step in the SageMaker deployment workflow. Never generate a bare `create_endpoint` call without these defaults — endpoints without autoscaling or alarms are demos, not deployments.

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Excel (.xlsx) manipulation via MCP server. Use for creating workbooks, formatting cells, writing formulas, building charts, pivot tables, data analysis, or any task involving Excel spreadsheets.

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Use Hugging Face Hub via MCP server tools. Search models, datasets, Spaces, papers. Get repo details, fetch documentation, run compute jobs, and use Gradio Spaces as AI tools. Available when connected to the HF MCP server.

日本語の概要は準備中です。原文の説明を表示しています。