「strain」の検索結果

Voice agents represent the frontier of AI interaction - humans speaking naturally with AI systems. The challenge isn't just speech recognition and synthesis, it's achieving natural conversation flow with sub-800ms latency while handling interruptions, background noise, and emotional nuance. This skill covers two architectures: speech-to-speech (OpenAI Realtime API, lowest latency, most natural) and pipeline (STT→LLM→TTS, more control, easier to debug). Key insight: latency is the constraint. Hu

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Knowledge and utilities for creating animated GIFs optimized for Slack. Provides constraints, validation tools, and animation concepts. Use when users request animated GIFs for Slack like "make me a GIF of X doing Y for Slack."

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You extend the browser to give users superpowers. You understand the unique constraints of extension development - permissions, security, store policies. You build extensions that people install and actually use daily. You know the difference between a toy and a tool.

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You are a senior backend engineer operating production-grade services under strict architectural and reliability constraints. Use when routes, controllers, services, repositories, express middleware, or prisma database access.

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Constrain LLM output with grammars; guarantee valid JSON.

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Enforce Kubernetes admission policies using OPA Gatekeeper with ConstraintTemplates, Rego rules, and the Gatekeeper policy library.

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Provides miscellaneous CTF challenge techniques for problems that do not cleanly fit the main categories. Use for encoding puzzles, pyjails, bash jails, RF/SDR, DNS oddities, unicode tricks, esoteric languages, QR or audio puzzles, constraint solving, game theory, unusual sandbox

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Generate project ideas via creative constraints.

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Design and create Busabase-backed App-in-Skill packages with a canonical app project, Busabase-native setup and product onboarding, review/execution workflows, a standardized responsive UI, and AirApp-first delivery. Use when a user wants a Busabase research desk, review queue, planner, action console, operating dashboard, control panel, collaboration workspace, onboarding/readiness flow, or an existing Kelly App-based skill updated. Every generated skill contains a complete app/ project, deploys that source to Busabase AirApp by default, runs pnpm dev only when local preview is explicitly requested, follows the Kelly desktop and phone UI contract, delegates AirApp runtime, SDK, security, scaffolding, and deployment constraints to busabase-app-creator, and delegates repository-level conformance testing to kelly-app-skill-creator-tests.

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Generates publish-ready LinkedIn posts for B2B SaaS marketing leaders writing from an operator point of view: real decisions, real trade-offs, real constraints, and defensible lessons. Use when turning an internal observation, framework, campaign decision, miss, or shipped artifact into a public LinkedIn post. Best for demand generation, ABM, marketing ops, product marketing, and SaaS GTM leaders building credibility through practical operating insight. Not intended for generic brand posts, company announcements, sales outreach, or long-form content.

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Finish an existing Japanese business talking-head, lecture, interview, or testimonial rough cut as a credibility-first vertical social video. Use when the user wants an SNS short that preserves the speaker's meaning while tightening repeated ideas, adding a first-second thesis, readable full captions, restrained punch-ins, speaker identification, a registered CTA card, dialogue-first audio, and retention QA.

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Toolkit for creating animated GIFs optimized for Slack, with validators for size constraints and composable animation primitives. This skill applies when users request animated GIFs or emoji animations for Slack from descriptions like "make me a GIF for Slack of X doing Y".

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Knowledge and utilities for creating animated GIFs optimized for Slack. Provides constraints, validation tools, and animation concepts. Use when users request animated GIFs for Slack like "make me a GIF of X doing Y for Slack."

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Design database schemas — tables, relationships, indexes, constraints, and ORM setup. Covers relational design, normalization, and common patterns.

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Designs genomics experiments so technical nuisance variation (batch, lane, plate, flow cell, operator, reagent lot, processing day) is balanced against the biological variable of interest and therefore estimable rather than confounded, using constrained sample-to-batch assignment (designit, OSAT), the confounder/mediator/collider distinction, and the principle that no post-hoc correction recovers a fully confounded design. Covers detecting hidden batches with surrogate variable analysis, a decision table for downstream correction (ComBat-seq, RUVSeq, SVA) whose execution is deferred to differential-expression/batch-correction, and reproducibility metadata. Use when assigning samples to sequencing batches/lanes/plates, avoiding batch-condition confounding, deciding whether a design is salvageable by correction, choosing a correction method, or estimating the number of hidden batches. For the experimental unit, randomization, and blocking concepts see experimental-design/randomization-blocking.

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Discover governing equations from data using PySR (evolutionary symbolic regression). Physics-constrained search with dimensional analysis, custom operators, and complexity-accuracy tradeoffs. Use when you need an interpretable equation, not a black-box model.

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This skill should be used at the start of any computationally intensive scientific task to detect and report available system resources (CPU cores, GPUs, memory, disk space). It creates a JSON file with resource information and strategic recommendations that inform computational approach decisions such as whether to use parallel processing (joblib, multiprocessing), out-of-core computing (Dask, Zarr), GPU acceleration (PyTorch, JAX), or memory-efficient strategies. Use this skill before running analyses, training models, processing large datasets, or any task where resource constraints matter.

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Authors reproducible bioinformatics pipelines with Snakemake - rules wired by output-file pattern, wildcards and expand() for sample fan-out, checkpoints for runtime-unknown outputs, resource/retry escalation, and conda/container software deployment on HPC and cloud. Use when deciding rule-based (Snakemake) vs channel/dataflow (Nextflow) authoring; wiring rules by OUTPUT-file pattern rather than imperative order; using wildcards + expand() for sample fan-out and constraining them to stop silent mis-routing; adding checkpoints when the set of outputs is unknown until a step runs (dynamic DAG); diagnosing why a job reran (or did not) under the mtime-plus-provenance trigger set; escalating memory on retry for OOM-killed jobs; and porting a Snakemake 7 `--cluster`/remote-provider command to the Snakemake 8+ executor-plugin and storage-plugin model (snakemake-executor-plugin-slurm) with `--software-deployment-method`.

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End-to-end eDNA metabarcoding from raw amplicons to community ecology. Covers QC, primer removal (mandatory before DADA2 filterAndTrim), denoising with OBITools3 v3 (obi stats plural; DMS-based) or DADA2 ASVs (Callahan 2017), decontam combined method as screening-not-classifier (Davis 2018), tag-jumping with NovaSeq 10x MiSeq caveat (Schnell 2015), Hill-number effective species counts with coverage-based rarefaction (Jost 2006; Chao & Jost 2012; doubling rule), beta-diversity decomposition with MANDATORY PERMANOVA + PERMDISP pair (Anderson & Walsh 2013), constrained ordination, and the read-counts-not-abundance critique (Lamb 2019). Use when processing eDNA samples for biodiversity assessment, deciding ASV vs OTU, configuring OBITools3 v3, interpreting decontam screening, or reporting community comparisons with the dispersion confound check.

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Multi-objective optimization framework. NSGA-II, NSGA-III, MOEA/D, Pareto fronts, constraint handling, benchmarks (ZDT, DTLZ), for engineering design and optimization problems.

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Designs and analyzes stable-isotope-resolved metabolomics (SIRM / isotope tracing / fluxomics) experiments that measure metabolic ACTIVITY via 13C/15N/2H tracers, distinct from steady-state pool profiling. Covers tracer choice, isotopologue vs isotopomer, mass-isotopomer distributions (MID), fractional enrichment, the mandatory natural-abundance + tracer-purity correction (IsoCor, AccuCor), and the metabolic/isotopic steady-state vs non-stationary (INST-MFA) distinction. Use when feeding a labeled tracer and interpreting labeling patterns, correcting raw isotopologue intensities, computing or plotting an MID, or deciding tracing vs abundance profiling. For absolute pool concentration and MRM mechanics see metabolomics/targeted-analysis; for constraint-based genome-scale flux (FBA, not empirical tracing) see systems-biology/flux-balance-analysis; for feature detection see metabolomics/xcms-preprocessing; for pathway enrichment that ignores the pool-vs-flux caveat see metabolomics/pathway-mapping.

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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

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Validates docked / generated protein-ligand poses using PoseBusters physical-validity tests, strain energy quantification, geometric checks (planarity, vdW overlap, bond/angle distortion), and pose-energy reasonableness. Filters AI-docking outputs (DiffDock, EquiBind, NeuralPLexer) where ~50% of poses fail physical-validity tests. Use when QC-ing docking results, comparing classical vs ML docking outputs, or filtering pose lists before SAR analysis.

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Apple's approach to interface design and fluid, physical motion, translated for the web. Use when building or reviewing gesture-driven UI, spring animations, drag/swipe/sheet interactions, momentum and interruptible transitions, translucent materials and depth, typography (optical sizing, tracking, leading), reduced-motion, or the design foundations (feedback, spatial consistency, restraint) behind Apple-style interfaces.

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